Fourier Transform Infrared spectroscopy of Bcl-2 protein

Author:

Anthony Jones

Mentor:

Kenneth Ralph Rodriguez, Associate Professor of Chemistry, CSU Dominguez Hills

B-cell lymphoma is a major protein responsible for the longevity of cancer cells. Bcl-2 stops cancerous cells from undergoing apoptosis, which enables them to keep surviving as well as growing. The purpose of this ongoing research is to incorporate the Bcl-2 protein onto a Self Assembled Monolayer (SAM) made from metallic microarray mesh. The structural properties as well as reactions of the immobilized protein with its natural inhibitors can be studied using the infrared extraordinary transmission of metallic microarrays (which involves transmitting more light than that incident on the holes). The study of Bcl-2 and through FTIR can lead to much information about the process of the binding and inhibitory processes which occurs in cells. The Assembly of Copper and Nickel microarray meshes show a high signal to noise ratio of micro-molar concentrations of proteins, which are embedded in the monolayer


Presented by:


Date:

Saturday, November 23, 2013

Poster:

67

Room:

Poster Session 3 - Villalobos Hall

Presentation Type:

Poster Presentation

Discipline:

Chemistry